Issue 48, 2009

Naphthalimide gold(i) phosphine complexes as anticancer metallodrugs

Abstract

Gold(I) phosphine complexes exhibit promising properties for anticancer drug development. Here we report on a series of gold(I) phosphine complexes containing a naphthalimide ligand. Strong antiproliferative effects were observed in MCF-7 breast cancer cells as well as in HT-29 colon carcinoma cells. The cellular and nuclear gold levels were increased compared to analogues, in which the naphthalimide ligand was replaced by a chloro ligand. Compound 4a was selected for more detailed biochemical and biological studies, which revealed solvent dependent fluorescence emission, uptake of the compound into the organelles of tumor cells as well as antiangiogenic effects concerning angiogenesis and tumor-induced angiogenesis in vivo. Antiangiogenic properties of 4a were observed in two different zebrafish angiogenesis models, including a tumor-cell induced neovascularization assay.

Graphical abstract: Naphthalimide gold(i) phosphine complexes as anticancer metallodrugs

Supplementary files

Article information

Article type
Paper
Submitted
24 Jun 2009
Accepted
07 Oct 2009
First published
28 Oct 2009

Dalton Trans., 2009, 10799-10805

Naphthalimide gold(I) phosphine complexes as anticancer metallodrugs

C. P. Bagowski, Y. You, H. Scheffler, D. H. Vlecken, D. J. Schmitz and I. Ott, Dalton Trans., 2009, 10799 DOI: 10.1039/B912378D

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