Issue 37, 2009
From the journal:

Chemical Communications

Convenient modular method for affinity labeling (MoAL method) based on a catalytic amidation†

Munetaka Kunishima,*ac   Shuichi Nakanishi,a   Jin Nishida,b   Hiroyuki Tanaka,a   Daiki Morisaki,a   Kazuhito Hiokibc  and  Hiroshi Nomotod  

* Corresponding authors

a Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan
E-mail: kunisima@p.kanazawa-u.ac.jp
Fax: (+81) 76-264-6201
Tel: (+81) 76-264-6201

b Faculty of Pharmaceutical Sciences, Kobe Gakuin University, 1-1-3 Minatojima Chuo-ku, Kobe 655-8586, Japan

c Cooperative Research Center of Life Sciences, Kobe Gakuin University, 1-1-3 Minatojima Chuo-ku, Kobe 655-8586, Japan

d College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama 790-8578, Japan

Abstract

A modular methodology for affinity labeling, in which three essential elements generally constituting affinity probes are prepared separately as individual molecules, has been developed based on a catalytic amidation.

Graphical abstract: Convenient modular method for affinity labeling (MoAL method) based on a catalytic amidation

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Article information

DOI
https://doi.org/10.1039/B912908A
Article type
Communication
Submitted
30 Jun 2009
Accepted
12 Aug 2009
First published
19 Aug 2009

Chem. Commun., 2009, 5597-5599

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Convenient modular method for affinity labeling (MoAL method) based on a catalytic amidation

M. Kunishima, S. Nakanishi, J. Nishida, H. Tanaka, D. Morisaki, K. Hioki and H. Nomoto, Chem. Commun., 2009, 5597 DOI: 10.1039/B912908A

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