Issue 9, 2010
From the journal:

Chemical Communications

Highly diastereoselective Friedel–Crafts reaction of indoles with an N-tert-butanesulfinylimino ester: an efficient and practical approach to enantiomerically enriched α-(3-indolyl)glycines†

Du-Ming Jia  and  Ming-Hua Xu*ab  

* Corresponding authors

a Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, P. R. China
E-mail: xumh@mail.shcnc.ac.cn
Fax: +86 215080 7388
Tel: +86 215080 7388

b State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, P. R. China

Abstract

An efficient, mild and general method for the preparation of highly enantiomerically enriched α-(3-indolyl)glycines by the transition-metal-based Lewis acid-catalyzed diastereoselective Friedel–Crafts reaction of indoles with an N-tert-butanesulfinylimino ester has been developed.

Graphical abstract: Highly diastereoselective Friedel–Crafts reaction of indoles with an N-tert-butanesulfinylimino ester: an efficient and practical approach to enantiomerically enriched α-(3-indolyl)glycines

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/B914687C
Article type
Communication
Submitted
21 Jul 2009
Accepted
11 Jan 2010
First published
27 Jan 2010

Chem. Commun., 2010,46, 1550-1552

Permissions

Request permissions

Highly diastereoselective Friedel–Crafts reaction of indoles with an N-tert-butanesulfinylimino ester: an efficient and practical approach to enantiomerically enriched α-(3-indolyl)glycines

D. Ji and M. Xu, Chem. Commun., 2010, 46, 1550 DOI: 10.1039/B914687C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements