Issue 43, 2009
From the journal:

Chemical Communications

Bromomaleimides: new reagents for the selective and reversible modification of cysteine†

Lauren M. Tedaldi,a   Mark E. B. Smith,a   Ramiz I. Nathania  and  James R. Baker*a  

* Corresponding authors

a Department of Chemistry, University College London, 20 Gordon St, London, UK
E-mail: j.r.baker@ucl.ac.uk
Fax: +44 (0)2076797463
Tel: +44 (0)2076792653

Abstract

Bromomaleimides react rapidly and selectively with cysteine to afford thiomaleimides which can be cleaved with a phosphine to regenerate the cysteine or treated with a base to afford dehydroalanine.

Graphical abstract: Bromomaleimides: new reagents for the selective and reversible modification of cysteine

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Article information

DOI
https://doi.org/10.1039/B915136B
Article type
Communication
Submitted
24 Jul 2009
Accepted
03 Sep 2009
First published
16 Sep 2009

Chem. Commun., 2009, 6583-6585

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Bromomaleimides: new reagents for the selective and reversible modification of cysteine

L. M. Tedaldi, M. E. B. Smith, R. I. Nathani and J. R. Baker, Chem. Commun., 2009, 6583 DOI: 10.1039/B915136B

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