Issue 12, 2009
From the journal:

Green Chemistry

Suzuki-Miyaura cross-coupling catalyzed by protein-stabilized palladium nanoparticles under aerobic conditions in water: application to a one-pot chemoenzymatic enantioselective synthesis of chiral biaryl alcohols†

A. Prastaro,a   P. Ceci,bc   E. Chiancone,bc   A. Boffi,bc   R. Cirilli,d   M. Colone,e   G. Fabrizi,a   A. Stringaroe  and  S. Cacchi*a  

* Corresponding authors

a Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza, Università di Roma, P.le A. Moro 5, Rome, Italy
E-mail: sandro.cacchi@uniroma1.it
Fax: +39 (06) 4991-2780
Tel: +39 (06) 4991-2795

b Dipartimento di Scienze Biochimiche, Sapienza, Università di Roma, P.le A. Moro 5, Rome, Italy
Fax: +39 (06) 4440062
Tel: +39 (06) 49910990

c Istituto di Biologia e Patologia Molecolari CNR, P.le A. Moro 5, Rome, Italy
E-mail: emilia.chiancone@uniroma1.it
Fax: +39 (06) 4440062
Tel: +39 (06) 49910761

d Dipartimento del Farmaco, Istituto Superiore di Sanità, Viale Regina Elena 299, Rome, Italy

e Dipartimento di Tecnologia e Salute, Istituto Superiore di Sanità, Viale Regina Elena 299, Rome, Italy

Abstract

The preparation of palladium nanoparticles stabilized primarily within the protein cavity of a highly thermostable Dps protein (DNA binding protein from starved cells) and the use of this precatalyst system in Suzuki-Miyaura cross-coupling reactions under aerobic conditions in water is described, as well as a two-step one-pot Suzuki-Miyaura cross-coupling followed by an enantioselective enzyme-catalyzed reduction to form chiral biaryl alcohols.

Graphical abstract: Suzuki-Miyaura cross-coupling catalyzed by protein-stabilized palladium nanoparticles under aerobic conditions in water: application to a one-pot chemoenzymatic enantioselective synthesis of chiral biaryl alcohols

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Article information

DOI
https://doi.org/10.1039/B915184B
Article type
Communication
Submitted
27 Jul 2009
Accepted
15 Sep 2009
First published
30 Sep 2009

Green Chem., 2009,11, 1929-1932

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Suzuki-Miyaura cross-coupling catalyzed by protein-stabilized palladium nanoparticles under aerobic conditions in water: application to a one-pot chemoenzymatic enantioselective synthesis of chiral biaryl alcohols

A. Prastaro, P. Ceci, E. Chiancone, A. Boffi, R. Cirilli, M. Colone, G. Fabrizi, A. Stringaro and S. Cacchi, Green Chem., 2009, 11, 1929 DOI: 10.1039/B915184B

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