Issue 3, 2010
From the journal:

Chemical Communications

Gd-functionalised Aunanoparticles as targeted contrast agents in MRI: relaxivity enhancement by polyelectrolyte coating†

Muhammad Farooq Warsi,a   Ralph W. Adams,a   Simon B. Ducketta  and  Victor Chechik*a  

* Corresponding authors

a Department of Chemistry, University of York, Heslington, York, UK
E-mail: vc4@york.ac.uk

Abstract

Monolayer-protected, Gd3+-functionalised gold nanoparticles with enhanced spin–lattice relaxivity (r1) were prepared; adsorption of polyelectrolytes on these materials further increased r1 and ligand exchange with a biotin-derivatised disulfide led to a prototype avidin-targeted contrast agent.

Graphical abstract: Gd-functionalised Au nanoparticles as targeted contrast agents in MRI: relaxivity enhancement by polyelectrolyte coating

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Article information

DOI
https://doi.org/10.1039/B915223G
Article type
Communication
Submitted
27 Jul 2009
Accepted
13 Nov 2009
First published
02 Dec 2009

Chem. Commun., 2010,46, 451-453

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Gd-functionalised Au nanoparticles as targeted contrast agents in MRI: relaxivity enhancement by polyelectrolyte coating

M. F. Warsi, R. W. Adams, S. B. Duckett and V. Chechik, Chem. Commun., 2010, 46, 451 DOI: 10.1039/B915223G

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