Issue 5, 2010

Mussel-inspired molecularly imprinted polymer coating superparamagnetic nanoparticles for protein recognition

Abstract

In this work, we report a facile approach for imprinting protein based on self-polymerization of dopamine in the presence of template protein on the Fe3O4 nanoparticles (NPs) surface. Dopamine, commonly known as a neurotransmitter, is also a small-molecule mimic of the adhesive proteins of mussels. Self-polymerization of dopamine can produce a thin polydopamine (PDA) layer on Fe3O4 NPs surface. During the self-polymerization of dopamine, some template protein molecules were embedded in the PDA layer. After the removal of these embedded protein molecules, the protein imprinted sites are created. The prepared imprinted Fe3O4@PDA NPs shows high binding capacity and acceptable specific recognition behavior towards template proteins.

Graphical abstract: Mussel-inspired molecularly imprinted polymer coating superparamagnetic nanoparticles for protein recognition

Supplementary files

Article information

Article type
Paper
Submitted
13 Aug 2009
Accepted
29 Oct 2009
First published
07 Dec 2009

J. Mater. Chem., 2010,20, 880-883

Mussel-inspired molecularly imprinted polymer coating superparamagnetic nanoparticles for protein recognition

W. Zhou, C. Lu, X. Guo, F. Chen, H. Yang and X. Wang, J. Mater. Chem., 2010, 20, 880 DOI: 10.1039/B916619J

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