Issue 5, 2010
From the journal:

Chemical Communications

High fluorescence selectivity and visual detection ofG-quadruplex structures by a novel dinuclear ruthenium complex†

Liang Xu,‡a   Dan Zhang,‡a   Jing Huang,a   Minggang Deng,a   Ming Zhanga  and  Xiang Zhou*ab  

* Corresponding authors

a College of Chemistry and Molecular Sciences, Key Laboratory of Biomedical Polymers of Ministry of Education, State Key Laboratory of Virology, Wuhan University, Hubei, Wuhan, P. R. China
E-mail: xzhou@whu.edu.cn
Fax: +86-27-87336380
Tel: +86-27-61056559

b State Key Laboratory of Natural and Biomimetic Drugs, Beijing University, State Key Laboratory of Applied Organic Chemistry, Lanzhou University, P. R. China

Abstract

A novel dinuclear ruthenium(II) complex with high fluorescent selectivity between DNA quadruplex structures and duplex structures was generated, and using an iodide-quenching strategy, G-quadruplex structures can be easily distinguished from duplex structures by the naked eye.

Graphical abstract: High fluorescence selectivity and visual detection of G-quadruplex structures by a novel dinuclear ruthenium complex

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Article information

DOI
https://doi.org/10.1039/B918045A
Article type
Communication
Submitted
03 Sep 2009
Accepted
03 Nov 2009
First published
26 Nov 2009

Chem. Commun., 2010,46, 743-745

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High fluorescence selectivity and visual detection of G-quadruplex structures by a novel dinuclear ruthenium complex

L. Xu, D. Zhang, J. Huang, M. Deng, M. Zhang and X. Zhou, Chem. Commun., 2010, 46, 743 DOI: 10.1039/B918045A

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