Issue 3, 2010
From the journal:

Chemical Communications

Unique metabolites of Pestalotiopsis fici suggest a biosynthetic hypothesis involving a Diels–Alder reaction and then mechanistic diversification†

Ling Liu,a   Shubin Niu,a   Xinhua Lu,b   Xulin Chen,c   Hua Zhang,b   Liangdong Guoa  and  Yongsheng Che*a  

* Corresponding authors

a Key Laboratory of Systematic Mycology & Lichenology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, People’s Republic of China
E-mail: cheys@im.ac.cn
Fax: +86 10 8261 8785

b New Drug Research and Development Center, North China Pharmaceutical Group Corporation, Shijiazhuang 050015, People’s Republic of China

c State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, People’s Republic of China

Abstract

Chloropupukeanolides A (1) and B (2), unprecedented spiroketal peroxides, and chloropupukeanone A (3), three highly functionalized metabolites featuring a chlorinated pupukeanane core, were isolated from an endophytic fungus Pestalotiopsis fici, with 1 showing significant anti-HIV-1 and cytotoxic effects.

Graphical abstract: Unique metabolites of Pestalotiopsis fici suggest a biosynthetic hypothesis involving a Diels–Alder reaction and then mechanistic diversification

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Article information

DOI
https://doi.org/10.1039/B918330B
Article type
Communication
Submitted
17 Sep 2009
Accepted
23 Oct 2009
First published
13 Nov 2009

Chem. Commun., 2010,46, 460-462

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Unique metabolites of Pestalotiopsis fici suggest a biosynthetic hypothesis involving a Diels–Alder reaction and then mechanistic diversification

L. Liu, S. Niu, X. Lu, X. Chen, H. Zhang, L. Guo and Y. Che, Chem. Commun., 2010, 46, 460 DOI: 10.1039/B918330B

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