Issue 7, 2010
From the journal:

Chemical Communications

Small molecule probes that target Ablkinase†

Karunakaran A. Kalesh,a   Derek S. B. Sim,a   Jigang Wang,b   Kai Liu,b   Qingsong Linb  and  Shao Q. Yao*abc  

* Corresponding authors

a Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543

b Department of Biological Sciences, National University of Singapore, 3 Science Drive 3, Singapore 117543

c NUS MedChem Program of the Life Sciences Institute, National University of Singapore, 3 Science Drive 3, Singapore 117543
E-mail: chmyaosq@nus.edu.sg
Fax: (+65) 67791691
Tel: (+65) 65162925

Abstract

Two different strategies, namely a dialdehyde-based cross-linking and photo-affinity labeling, have been developed to generate small molecule activity-based probes (ABPs) for the Abelson (Abl) tyrosine kinase, of which probe 13, derived from the photo-affinity approach, showed specific labeling of Abl kinase present in a crude mammalian proteome.

Graphical abstract: Small molecule probes that target Abl kinase

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Article information

DOI
https://doi.org/10.1039/B919888A
Article type
Communication
Submitted
23 Sep 2009
Accepted
25 Nov 2009
First published
14 Dec 2009

Chem. Commun., 2010,46, 1118-1120

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Small molecule probes that target Abl kinase

K. A. Kalesh, D. S. B. Sim, J. Wang, K. Liu, Q. Lin and S. Q. Yao, Chem. Commun., 2010, 46, 1118 DOI: 10.1039/B919888A

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