Issue 4, 2010
From the journal:

Organic & Biomolecular Chemistry

New and simple synthesis of acid azides, ureas and carbamates from carboxylic acids: application of peptide coupling agents EDC and HBTU†

Vommina V. Sureshbabu,*a   H. S. Lalithamba,a   N. Narendraa  and  H. P. Hemanthaa  

* Corresponding authors

a Peptide Research Laboratory, Department of Studies in Chemistry, Central College Campus, Bangalore University, Dr. B. R. Ambedkar Veedhi, Bangalore – 560 001, India
E-mail: sureshbabuvommina@rediffmail.com, hariccb@hotmail.com

Abstract

Conversion of carboxylic acids into acid azides using peptide coupling agents, EDC and HBTU is described. The procedure is efficient, practical and applicable to a diverse range of carboxylic acids including N-protected amino acids. Using the same reagents, one-pot synthesis of ureas, dipeptidyl urea esters and carbamates from acids has also been achieved.

Graphical abstract: New and simple synthesis of acid azides, ureas and carbamates from carboxylic acids: application of peptide coupling agents EDC and HBTU

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Article information

DOI
https://doi.org/10.1039/B920290K
Article type
Paper
Submitted
29 Sep 2009
Accepted
06 Nov 2009
First published
08 Dec 2009

Org. Biomol. Chem., 2010,8, 835-840

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New and simple synthesis of acid azides, ureas and carbamates from carboxylic acids: application of peptide coupling agents EDC and HBTU

V. V. Sureshbabu, H. S. Lalithamba, N. Narendra and H. P. Hemantha, Org. Biomol. Chem., 2010, 8, 835 DOI: 10.1039/B920290K

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