Issue 8, 2010
From the journal:

Chemical Communications

Facile and rapid manipulation of DNA surface density on gold nanoparticles using mononucleotide-mediated conjugation†

Wenting Zhaoa  and  I-Ming Hsing*ab  

* Corresponding authors

a Bioengineering Graduate Program, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China

b Department of Chemical and Biomolecular Engineering, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China
E-mail: kehsing@ust.hk
Fax: +852 3106 4857
Tel: +852 2358 7131

Abstract

We report here a method to manipulate the amount of thiolated DNA attached per gold nanoparticle from a few to tens of strands in less than an hour, which involves the tuning of the respective amount of salt and time of addition of thiolated oligo(ethylene glycol) during mononucleotide-mediated conjugation process.

Graphical abstract: Facile and rapid manipulation of DNA surface density on gold nanoparticles using mononucleotide-mediated conjugation

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Article information

DOI
https://doi.org/10.1039/B920696E
Article type
Communication
Submitted
06 Oct 2009
Accepted
18 Dec 2009
First published
15 Jan 2010

Chem. Commun., 2010,46, 1314-1316

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Facile and rapid manipulation of DNA surface density on gold nanoparticles using mononucleotide-mediated conjugation

W. Zhao and I. Hsing, Chem. Commun., 2010, 46, 1314 DOI: 10.1039/B920696E

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