Issue 12, 2010

Reaction of Fe3(CO)12 with octreotide—chemical, electrochemical and biological investigations

Abstract

In search for peptidic [FeFe] hydrogenase mimics, the cyclic disulfide Sandostatin® (octreotide) was allowed to react with Fe3(CO)12. An octreotide-Fe2(CO)6 complex was isolated and characterized spectroscopically as well as by elemental and thermochemical analysis. The complex catalyzes the electrochemical reduction of H+ to H2. It is suggested by radioligand binding assays that the complex retains much of the binding affinity for the somatostatin hsst1-5 receptors of octreotide.

Graphical abstract: Reaction of Fe3(CO)12 with octreotide—chemical, electrochemical and biological investigations

Article information

Article type
Paper
Submitted
12 Oct 2009
Accepted
13 Jan 2010
First published
02 Feb 2010

Dalton Trans., 2010,39, 3065-3071

Reaction of Fe3(CO)12 with octreotide—chemical, electrochemical and biological investigations

U. Apfel, M. Rudolph, C. Apfel, C. Robl, D. Langenegger, D. Hoyer, B. Jaun, M. Ebert, T. Alpermann, D. Seebach and W. Weigand, Dalton Trans., 2010, 39, 3065 DOI: 10.1039/B921299J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements