Issue 17, 2010

Squaramide-catalyzed enantioselective Friedel–Crafts reaction of indoles with imines

Abstract

Chiral squaramides are highly enantioselective catalysts for Friedel–Crafts reaction of indoles with N-tosyl imines, affording 3-indolyl methanamine products in 85–96% yields and 84–96% ees.

Graphical abstract: Squaramide-catalyzed enantioselective Friedel–Crafts reaction of indoles with imines

Supplementary files

Article information

Article type
Communication
Submitted
22 Oct 2009
Accepted
25 Feb 2010
First published
23 Mar 2010

Chem. Commun., 2010,46, 3004-3006

Squaramide-catalyzed enantioselective Friedel–Crafts reaction of indoles with imines

Y. Qian, G. Ma, A. Lv, H. Zhu, J. Zhao and V. H. Rawal, Chem. Commun., 2010, 46, 3004 DOI: 10.1039/B922120D

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