Issue 18, 2010
From the journal:

Chemical Communications

First principles design of derivatizing agent for direct determination of enantiomeric purity of chiral alcohols and amines by NMR spectroscopy†

Nikolay V. Orlova  and  Valentine P. Ananikov*a  

* Corresponding authors

a Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Pr. 47, Moscow, Russia
E-mail: val@ioc.ac.ru

Abstract

77Se NMR offers superior sensing of chirality within the structure of the diastereomers (Δδ up to 6.1 ppm), compared to 13C (Δδ < 1 ppm) and 1H (Δδ < 0.2 ppm). The developed procedure is equally well suitable for determination of the enantiomeric purity of chiral alcohols and amines as pure samples as well as reaction mixtures and crude products.

Graphical abstract: First principles design of derivatizing agent for direct determination of enantiomeric purity of chiral alcohols and amines by NMR spectroscopy

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Article information

DOI
https://doi.org/10.1039/B923359H
Article type
Communication
Submitted
09 Nov 2009
Accepted
22 Feb 2010
First published
19 Mar 2010

Chem. Commun., 2010,46, 3212-3214

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First principles design of derivatizing agent for direct determination of enantiomeric purity of chiral alcohols and amines by NMR spectroscopy

N. V. Orlov and V. P. Ananikov, Chem. Commun., 2010, 46, 3212 DOI: 10.1039/B923359H

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