Issue 4, 2010
From the journal:

Molecular BioSystems

Mutation of key residues in the C-methyltransferase domain of a fungal highly reducing polyketide synthase†

Elizabeth J. Skellam,a   Deirdre Hurley,a   Jack Davison,a   Colin M. Lazarus,b   Thomas J. Simpsona  and  Russell J. Cox*a  

* Corresponding authors

a School of Chemistry, University of Bristol, Cantock’s Close, Bristol, UK
E-mail: r.j.cox@bris.ac.uk
Fax: +44 (0) 1179298611
Tel: +44(0) 1179289184

b School of Biological Sciences, University of Bristol, Bristol, UK

Abstract

Site directed mutations of the C-methyltransferase domain of squalestatin tetraketide synthase were made in an attempt to alter the methylation pattern of the synthase expressed in vivo: mutation resulted in either no effect or in complete abrogation of polyketide production.

Graphical abstract: Mutation of key residues in the C-methyltransferase domain of a fungal highly reducing polyketide synthase

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Article information

DOI
https://doi.org/10.1039/B923990A
Article type
Communication
Submitted
16 Nov 2009
Accepted
21 Dec 2009
First published
10 Feb 2010

Mol. BioSyst., 2010,6, 680-682

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Mutation of key residues in the C-methyltransferase domain of a fungal highly reducing polyketide synthase

E. J. Skellam, D. Hurley, J. Davison, C. M. Lazarus, T. J. Simpson and R. J. Cox, Mol. BioSyst., 2010, 6, 680 DOI: 10.1039/B923990A

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