Facile oxidation of electron-poor benzo[b]thiophenes to the corresponding sulfones with an aqueous solution of H2O2 and P2O5

Dyeison Antonow; Teresa Marrafa; Irfaan Dawood; Tauheed Ahmed; Mohammad R. Haque; David E. Thurston; Giovanna Zinzalla

doi:10.1039/B924333J

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Facile oxidation of electron-poor benzo[b]thiophenes to the corresponding sulfones with an aqueous solution of H₂O₂ and P₂O₅†

Dyeison Antonow,^a Teresa Marrafa,^a Irfaan Dawood,^a Tauheed Ahmed,^a Mohammad R. Haque,^a David E. Thurston^a and Giovanna Zinzalla*^a

Author affiliations

* Corresponding authors

^a Cancer Research UK Protein-Protein Interactions Drug Discovery Research Group, The School of Pharmacy, University of London, 29-39 Brunswick Square, London, UK
E-mail: giovanna.zinzalla@pharmacy.ac.uk
Fax: +44 (0)207753 5964
Tel: +44 (0)207 7753 5932

Abstract

A facile oxidation for the clean conversion of benzo[b]thiophenes to their corresponding sulfones is described employing an aqueous solution of H₂O₂ and P₂O₅; the solution can be prepared and stored on a multi-gram scale with a shelf-life of up to two weeks.

Download options Please wait...

Supplementary files

Experimental details for preparation of the aqueous H2O2–P2O5 reagent and for all the reactions described. Full characterisation of all starting materials and products is also included PDF (17387K)

Article information

DOI: https://doi.org/10.1039/B924333J
Article type: Communication
Submitted: 19 Nov 2009
Accepted: 21 Dec 2009
First published: 25 Jan 2010

Download Citation

Chem. Commun., 2010,46, 2289-2291

Permissions

Request permissions

Facile oxidation of electron-poor benzo[b]thiophenes to the corresponding sulfones with an aqueous solution of H₂O₂ and P₂O₅

D. Antonow, T. Marrafa, I. Dawood, T. Ahmed, M. R. Haque, D. E. Thurston and G. Zinzalla, Chem. Commun., 2010, 46, 2289 DOI: 10.1039/B924333J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Chemical Communications