Issue 16, 2010
From the journal:

Chemical Communications

One-pot synthesis of substituted isoindolin-1-ones via lithiation and substitution of N′-benzyl-N,N-dimethylureas†

Keith Smith,*a   Gamal A. El-Hitia  and  Amany S. Hegazya  

* Corresponding authors

a School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff, UK
E-mail: smithk13@cardiff.ac.uk, el-hitiga@cardiff.ac.uk
Fax: +44 (0)2920870600
Tel: +44 (0)2920870600

Abstract

Lithiation of various N′-benzyl-N,N-dimethylureas with t-BuLi (3.3 mole equivalents) in anhydrous THF at 0 °C followed by reactions with various electrophiles afforded the corresponding 3-substituted isoindolin-1-ones in high yields.

Graphical abstract: One-pot synthesis of substituted isoindolin-1-ones via lithiation and substitution of N′-benzyl-N,N-dimethylureas

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Article information

DOI
https://doi.org/10.1039/B926983E
Article type
Communication
Submitted
22 Dec 2009
Accepted
13 Feb 2010
First published
25 Feb 2010

Chem. Commun., 2010,46, 2790-2792

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One-pot synthesis of substituted isoindolin-1-ones via lithiation and substitution of N′-benzyl-N,N-dimethylureas

K. Smith, G. A. El-Hiti and A. S. Hegazy, Chem. Commun., 2010, 46, 2790 DOI: 10.1039/B926983E

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