Issue 18, 2010
From the journal:

Dalton Transactions

Synthesis and DNA photocleavage study of Ru(bpy)32+-(CH2)n-MV2+ complexes†

Shiguo Sun,*a   Yanxia He,a   Zhigang Yang,a   Yi Pang,ab   Fengyu Liu,c   Jiangli Fan,a   Licheng Sund  and  Xiaojun Peng*a  

* Corresponding authors

a State Key Laboratory of Fine Chemicals, Dalian University of Technology, No. 158-40, Zhongshanlu, Xigang District, Dalian, China

b Department of Chemistry, The University of Akron, Akron, Ohio, USA

c Department of Chemistry and State Key Laboratory of Fine Chemicals, Dalian University of Technology, No. 2, Linggonglu, Ganjingzi District, Dalian, China

d Department of Chemistry, Organic Chemistry, Royal Institute of Technology(KTH), Teknikringen 30, Stockholm, Sweden

Abstract

A series of Ru(bpy)32+-(CH2)n-MV2+ complexes (1, n = 3, 4, 7) used for DNA photocleavage have been designed and synthesized. Under the irradiation of visible light, complexes 1 can cleave supercoiled plasmid DNA (pBR322) both in air and under Ar atmosphere. Radical species such as O2−˙, ˙OH and the light-induced charge-separated (CS) oxidation state Ru(bpy)33+-(CH2)n-MV+˙ are responsible for the cleavage. The longer the carbon chain linkage, the higher the DNA photocleavage efficiency. It is noted that backwards intramolecular electron transfer (ET) that exist in complexes 1 can lead to some decreasing effect on the cleavage result, while inclusion of complexes 1 with cucurbit[8]uril (CB[8]) inhibits the backwards ET to some extent, thereby increasing photocleavage efficiency.

Graphical abstract: Synthesis and DNA photocleavage study of Ru(bpy)32+-(CH2)n-MV2+ complexes

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Article information

DOI
https://doi.org/10.1039/B927568A
Article type
Paper
Submitted
05 Jan 2010
Accepted
12 Feb 2010
First published
29 Mar 2010

Dalton Trans., 2010,39, 4411-4416

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Synthesis and DNA photocleavage study of Ru(bpy)32+-(CH2)n-MV2+ complexes

S. Sun, Y. He, Z. Yang, Y. Pang, F. Liu, J. Fan, L. Sun and X. Peng, Dalton Trans., 2010, 39, 4411 DOI: 10.1039/B927568A

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