Issue 22, 2010

Cyclometalated gold(iii) complexes with N-heterocyclic carbene ligands as topoisomerase I poisons

Abstract

A panel of stable [Au(R–C⁁N⁁C)(N-heterocyclic carbene)]+ complexes displays prominent in vitro anticancer properties; [Au(C⁁N⁁C)(IMe)]CF3SO3 (1, IMe = 1,3-dimethylimidazol-2-ylidene) significantly poisons topoisomerase I in vitro and suppresses tumor growth in nude mice model.

Graphical abstract: Cyclometalated gold(iii) complexes with N-heterocyclic carbene ligands as topoisomerase I poisons

Supplementary files

Article information

Article type
Communication
Submitted
19 Jan 2010
Accepted
19 Mar 2010
First published
19 Apr 2010

Chem. Commun., 2010,46, 3893-3895

Cyclometalated gold(III) complexes with N-heterocyclic carbene ligands as topoisomerase I poisons

J. J. Yan, A. L. Chow, C. Leung, R. W. Sun, D. Ma and C. Che, Chem. Commun., 2010, 46, 3893 DOI: 10.1039/C001216E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements