Issue 23, 2010
From the journal:

Chemical Communications

Glucosamine hydrochloride functionalized tetraphenylethylene: A novel fluorescent probe for alkaline phosphatase based on the aggregation-induced emission†

Qi Chen,a   Ning Bian,ab   Chun Cao,a   Xi-Long Qiu,ab   Ai-Di Qib  and  Bao-Hang Han*a  

* Corresponding authors

a National Center for Nanoscience and Technology, Beijing 100190, China
E-mail: hanbh@nanoctr.cn
Fax: +86-10-82545576

b College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China

Abstract

Grafting of glucosamine hydrochloride moieties to tetraphenylethylene (TPE) motif furnished a novel cationic water-soluble tetraphenylethylene derivative (GH-TPE). With aggregation-induced emission properties, GH-TPE was used for fluorometric detection to alkaline phosphatase through enzyme-triggered de-aggregation of the ensemble of GH-TPE and substrate.

Graphical abstract: Glucosamine hydrochloride functionalized tetraphenylethylene: A novel fluorescent probe for alkaline phosphatase based on the aggregation-induced emission

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Article information

DOI
https://doi.org/10.1039/C002894K
Article type
Communication
Submitted
11 Feb 2010
Accepted
10 Apr 2010
First published
10 May 2010

Chem. Commun., 2010,46, 4067-4069

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Glucosamine hydrochloride functionalized tetraphenylethylene: A novel fluorescent probe for alkaline phosphatase based on the aggregation-induced emission

Q. Chen, N. Bian, C. Cao, X. Qiu, A. Qi and B. Han, Chem. Commun., 2010, 46, 4067 DOI: 10.1039/C002894K

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