Selective mitochondrial accumulation of cytotoxic dinuclear polypyridyl ruthenium(II) complexes

Michelle J. Pisani; Daniel K. Weber; Kirsten Heimann; J. Grant Collins; F. Richard Keene

doi:10.1039/C004922K

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Selective mitochondrial accumulation of cytotoxic dinuclear polypyridyl ruthenium(ii) complexes

Michelle J. Pisani,^a Daniel K. Weber,^b Kirsten Heimann,^c J. Grant Collins*^a and F. Richard Keene*^b

Author affiliations

* Corresponding authors

^a School of Physical, Environmental and Mathematical Sciences, University of New South Wales, Australian Defence Force Academy, Canberra, Australia

^b School of Pharmacy and Molecular Sciences, James Cook University, Townsville, Australia
E-mail: richard.keene@jcu.edu.au
Fax: +61 7 4781 6078

^c School of Marine and Tropical Biology, James Cook University, Townsville, Australia

Abstract

The lipophilic ligand-bridged dinuclear cation Rubb₁₆ is significantly cytotoxic and preferentially accumulates in the mitochondria of the L1210 murine leukemia cancer cell line.

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Article information

DOI: https://doi.org/10.1039/C004922K
Article type: Communication
Submitted: 04 Feb 2010
Accepted: 15 Apr 2010
First published: 23 Apr 2010

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Metallomics, 2010,2, 393-396

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Metallomics

Selective mitochondrial accumulation of cytotoxic dinuclear polypyridyl ruthenium(ii) complexes

Abstract

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