Issue 7, 2010

Moving posttranslational modifications forward to biosynthesize the glycosylated thiopeptide nocathiacin I in Nocardia sp. ATCC202099

Abstract

Characterization of the biosynthetic gene cluster of glycosylated antibiotic nocathiacin I (NOC-I) here adds new insights to thiopeptide biosynthesis, showing the NOC-specific tailoring and unusual sugar formation. NOC-I biosynthesis shares the paradigm for forming a common thiopeptide core and the generality for converting to an e series member, as that of the parent compound nosiheptide (NOS). This may permit the production of NOC-I in the genetically amenable, NOS-producing strain by building NOC-specific genes for pathway engineering.

Graphical abstract: Moving posttranslational modifications forward to biosynthesize the glycosylated thiopeptide nocathiacin I in Nocardia sp. ATCC202099

Supplementary files

Article information

Article type
Communication
Submitted
15 Apr 2010
Accepted
05 May 2010
First published
17 May 2010

Mol. BioSyst., 2010,6, 1180-1185

Moving posttranslational modifications forward to biosynthesize the glycosylated thiopeptide nocathiacin I in Nocardia sp. ATCC202099

Y. Ding, Y. Yu, H. Pan, H. Guo, Y. Li and W. Liu, Mol. BioSyst., 2010, 6, 1180 DOI: 10.1039/C005121G

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