Issue 10, 2010

Glyco-biosensors: Recent advances and applications for the detection of free and bound carbohydrates

Abstract

The field of biosensor development now encompasses several areas specifically geared toward the rapid and sensitive detection, identification, and quantification of target analytes. In contrast to the more mature research and development of nucleic acid and protein biosensors, the development of ‘glyco-biosensors’ for detecting carbohydrates and conjugates of carbohydrates (glycoconjugates) is at a relatively nascent stage. The application of glyco-biosensors aims to open novel analytical and diagnostic avenues, encompassing industrial bioprocesses, biomedical and clinical applications. This area of research has been greatly aided by advancement brought by interdisciplinary mergers of engineering, biology, chemistry and physical sciences and enabling the miniaturization of detection platforms. In this review, we briefly introduce the need for glyco-biosensors, discuss current analytical technologies, and examine advances in glyco-biosensor approaches aimed at the detection and/or quantification of glycoconjugates or carbohydrates derived from glycoconjugates since 2005.

Graphical abstract: Glyco-biosensors: Recent advances and applications for the detection of free and bound carbohydrates

Article information

Article type
Minireview
Submitted
29 Apr 2010
Accepted
06 Jun 2010
First published
11 Aug 2010

Analyst, 2010,135, 2471-2480

Glyco-biosensors: Recent advances and applications for the detection of free and bound carbohydrates

S. Cunningham, J. Q. Gerlach, M. Kane and L. Joshi, Analyst, 2010, 135, 2471 DOI: 10.1039/C0AN00276C

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