Issue 6, 2011

Continuous glucose monitoring by means of mid-infrared transmission laser spectroscopyin vitro

Abstract

The continuous surveillance of glucose concentration reduces short-term risks and long-term complications for people with diabetes mellitus, a disorder of glucose metabolism. As a first step towards the continuous monitoring of glucose, reagent-free transmission spectroscopy in the mid-infrared region has been carried out in vitro using a quantum cascade laser and an optical silver halide fiber. A 30 μm gap in the fiber allowed for transmission spectroscopy of aqueous glucose solutions at a wavelength of 9.69 μm, which is specific to a molecular vibration of glucose. A noise-equivalent concentration as low as 4 mg/dL was achieved at an average power of 1.8 mW and an integration time of 50 s. This is among the most precise of glucose measurements using mid-infrared spectroscopy. Even with the very low average laser power of 0.07 mW the sensitivity of previous results (using a fiber optical evanescent field analysis) has been improved upon by almost one order of magnitude. Finally, the impact of potentially interfering substances such as other carbohydrates was analyzed.

Graphical abstract: Continuous glucose monitoring by means of mid-infrared transmission laser spectroscopyin vitro

Article information

Article type
Paper
Submitted
17 Jul 2010
Accepted
21 Dec 2010
First published
27 Jan 2011

Analyst, 2011,136, 1192-1198

Continuous glucose monitoring by means of mid-infrared transmission laser spectroscopyin vitro

C. Vrančić, A. Fomichova, N. Gretz, C. Herrmann, S. Neudecker, A. Pucci and W. Petrich, Analyst, 2011, 136, 1192 DOI: 10.1039/C0AN00537A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements