Issue 6, 2011
From the journal:

Analyst

Antibody-based multiplex analysis of structurally closely related chiral molecules†

Tigabu Kassa,a   L. Pauli Undesser,b   Heike Hofstettera  and  Oliver Hofstetter*a  

* Corresponding authors

a Department of Chemistry and Biochemistry, Northern Illinois University, DeKalb, IL, USA
E-mail: ohofst@niu.edu
Fax: +1-815-7534802
Tel: +1-815-7536898

b Pierce Biotechnology-Thermo Fisher Scientific, Rockford, IL, USA

Abstract

Four class-specific and stereoselective antibodies were labeled with different fluorophores to enable simultaneous quantification of the enantiomers of phenylalanine and phenyllactic acid. Using fluorescence immunoassays and microarrays, sensitive detection of each analyte was possible even in the presence of a large excess of the other structurally similar molecules.

Graphical abstract: Antibody-based multiplex analysis of structurally closely related chiral molecules

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Article information

DOI
https://doi.org/10.1039/C0AN00814A
Article type
Communication
Submitted
22 Oct 2010
Accepted
03 Jan 2011
First published
17 Jan 2011

Analyst, 2011,136, 1113-1115

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Antibody-based multiplex analysis of structurally closely related chiral molecules

T. Kassa, L. P. Undesser, H. Hofstetter and O. Hofstetter, Analyst, 2011, 136, 1113 DOI: 10.1039/C0AN00814A

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