Issue 23, 2010

Palladium-catalyzed direct oxidative Heck–Cassar–Sonogashira type alkynylation of indoles with alkynes under oxygen

Abstract

A novel PdII catalyzed direct oxidative Heck–Cassar–Sonogashira type alkynylation of indoles with terminal alkynes under an atmosphere of O2 is developed. Unlike previous methods, the reaction does not require the pregeneration of indolyl halide or alkynyl halide. Furthermore, only a catalytic amount of base is required and oxygen was used as the ultimate “green” terminal oxidant.

Graphical abstract: Palladium-catalyzed direct oxidative Heck–Cassar–Sonogashira type alkynylation of indoles with alkynes under oxygen

Supplementary files

Article information

Article type
Communication
Submitted
18 Feb 2010
Accepted
01 Apr 2010
First published
04 May 2010

Chem. Commun., 2010,46, 4184-4186

Palladium-catalyzed direct oxidative Heck–Cassar–Sonogashira type alkynylation of indoles with alkynes under oxygen

L. Yang, L. Zhao and C. Li, Chem. Commun., 2010, 46, 4184 DOI: 10.1039/C0CC00014K

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