Issue 28, 2010
From the journal:

Chemical Communications

α,β-D-CNA preorganization of unpaired loop moiety stabilizes DNA hairpin†

Christelle Dupouy,a   Pierre Millard,a   Arnaud Boissonneta  and  Jean-Marc Escudier*a  

* Corresponding authors

a Laboratoire de Synthèse et Physico-Chimie de Molécules d’Intérêt Biologique, UMR 5068 CNRS, Université Paul Sabatier, 118 Route de Narbonne, 31062 Toulouse Cedex 9, France
E-mail: escudier@chimie.ups-tlse.fr
Fax: (+33) 5-6155-6011
Tel: (+33) 5-6155-6291

Abstract

DNA hairpin structures can be stabilized by introduction of constraint on the sugar phosphate backbone within the unpaired loop moiety by means of dinucleotides locked with an alpha torsion angle in gauche(+) configuration.

Graphical abstract: α,β-D-CNA preorganization of unpaired loop moiety stabilizes DNA hairpin

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Article information

DOI
https://doi.org/10.1039/C0CC00244E
Article type
Communication
Submitted
05 Mar 2010
Accepted
20 May 2010
First published
10 Jun 2010

Chem. Commun., 2010,46, 5142-5144

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α,β-D-CNA preorganization of unpaired loop moiety stabilizes DNA hairpin

C. Dupouy, P. Millard, A. Boissonnet and J. Escudier, Chem. Commun., 2010, 46, 5142 DOI: 10.1039/C0CC00244E

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