Issue 29, 2010
From the journal:

Chemical Communications

Synthesis of N-, S-, and C-glycoside castanospermine analogues with selective neutral α-glucosidase inhibitory activity as antitumour agents†

Elena M. Sánchez-Fernández,a   Rocío Rísquez-Cuadro,b   Maud Chasseraud,c   Ahmed Ahidouch,c   Carmen Ortiz Mellet,*b   Halima Ouadid-Ahidouch*c  and  José M. García Fernández*a  

* Corresponding authors

a Instituto de Investigaciones Químicas, CSIC, Américo Vespucio 49, Isla de la Cartuja, E-41092 Sevilla, Spain
E-mail: jogarcia@iiq.csic.es
Fax: +34 954460565
Tel: +34 954489559

b Departamento de Química Orgánica, Facultad de Química, Universidad de Sevilla, Apartado 553, E-41071 Sevilla, Spain
E-mail: mellet@us.es
Fax: +34 954624960
Tel: +34 954559806

c Laboratoire de Physiologie Cellulaire et Moléculaire, JE 2530: Canaux Ioniques dans le Cancer du Sein, Faculté des Sciences, Amiens, France
E-mail: ha-sciences@u-picardie.fr
Fax: +33 322827644

Abstract

sp2-Iminosugar-type castanospermine analogues bearing an α-configured N-, S-, or C-linked pseudoanomeric group have been designed as selective inhibitors of the neutral α-glucosidases involved in N-glycoprotein processing; evaluation in breast cancer cell growth indicated a significant antiproliferative potential that was dependent on the nature of the pseudoanomeric group.

Graphical abstract: Synthesis of N-, S-, and C-glycoside castanospermine analogues with selective neutral α-glucosidase inhibitory activity as antitumour agents

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Article information

DOI
https://doi.org/10.1039/C0CC00446D
Article type
Communication
Submitted
17 Mar 2010
Accepted
14 May 2010
First published
15 Jun 2010

Chem. Commun., 2010,46, 5328-5330

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Synthesis of N-, S-, and C-glycoside castanospermine analogues with selective neutral α-glucosidase inhibitory activity as antitumour agents

E. M. Sánchez-Fernández, R. Rísquez-Cuadro, M. Chasseraud, A. Ahidouch, C. O. Mellet, H. Ouadid-Ahidouch and J. M. G. Fernández, Chem. Commun., 2010, 46, 5328 DOI: 10.1039/C0CC00446D

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