Issue 34, 2010
From the journal:

Chemical Communications

Luminescent conjugates between dinuclear rhenium(i) complexes and peptide nucleic acids (PNA) for cell imaging and DNA targeting†

Elena Ferri,a   Daniela Donghi,b   Monica Panigati,b   Giuseppe Prencipe,a   Laura D'Alfonso,c   Ivan Zanoni,d   Clara Baldoli,e   Stefano Maiorana,a   Giuseppe D'Alfonso*b  and  Emanuela Licandro*a  

* Corresponding authors

a Dipartimento di Chimica Organica e Industriale, Università degli Studi di Milano, via Venezian 21, I-20133 Milano, Italy
E-mail: emanuela.licandro@unimi.it

b Dipartimento di Chimica Inorganica, Metallorganica e Analitica “L. Malatesta”, Università degli Studi di Milano, via Venezian 21, I-20133 Milano, Italy
E-mail: giuseppe.dalfonso@unimi.it

c Dipartimento di Fisica, Università di Milano-Bicocca, piazza della Scienza 3, I-20126 Milano, Italy

d Dipartimento di Biotecnologie e Bioscienze, Università di Milano-Bicocca, piazza della Scienza 2, I-20126 Milano, Italy

e Istituto di Scienze e Tecnologie Molecolari, C.N.R., Via C. Golgi 19, I-20133 Milano, Italy

Abstract

New luminescent dinuclear rhenium(I) tricarbonyl complex–PNA conjugates have been synthesized through a reliable solid-phase synthetic methodology. Their photophysical properties have been measured. The most luminescent Re–PNA conjugate 7 showed interesting two-photon absorption (TPA) properties, that were exploited for imaging experiments, to demonstrate its easy uptake into living cells.

Graphical abstract: Luminescent conjugates between dinuclear rhenium(i) complexes and peptide nucleic acids (PNA) for cell imaging and DNA targeting

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Article information

DOI
https://doi.org/10.1039/C0CC00450B
Article type
Communication
Submitted
17 Mar 2010
Accepted
30 Jun 2010
First published
29 Jul 2010

Chem. Commun., 2010,46, 6255-6257

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Luminescent conjugates between dinuclear rhenium(I) complexes and peptide nucleic acids (PNA) for cell imaging and DNA targeting

E. Ferri, D. Donghi, M. Panigati, G. Prencipe, L. D'Alfonso, I. Zanoni, C. Baldoli, S. Maiorana, G. D'Alfonso and E. Licandro, Chem. Commun., 2010, 46, 6255 DOI: 10.1039/C0CC00450B

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