Issue 31, 2010
From the journal:

Chemical Communications

A colorimetric and ratiometric fluorescent probe for thiols and its bioimaging applications†

Baocun Zhu,a   Xiaoling Zhang,*a   Yamin Li,a   Pengfei Wang,*b   Hongyan Zhangb  and  Xiaoqing Zhuangb  

* Corresponding authors

a Department of Chemistry, School of Science, Beijing Institute of Technology, Beijing 100081, P.R. China
E-mail: zhangxl@bit.edu.cn
Fax: 86-10-88875298
Tel: 86-10-88875298

b Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, P. R. China
E-mail: wangpf@mail.ipc.ac.cn

Abstract

A naphthalimide-based colorimetric fluorescent probe containing a disulfide group was designed and synthesized, which could detect the physiological level of GSH quantitatively by a ratiometric fluorescence method and was successfully applied to the imaging of thiols in living HeLa cells.

Graphical abstract: A colorimetric and ratiometric fluorescent probe for thiols and its bioimaging applications

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Article information

DOI
https://doi.org/10.1039/C0CC00477D
Article type
Communication
Submitted
19 Mar 2010
Accepted
11 Jun 2010
First published
01 Jul 2010

Chem. Commun., 2010,46, 5710-5712

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A colorimetric and ratiometric fluorescent probe for thiols and its bioimaging applications

B. Zhu, X. Zhang, Y. Li, P. Wang, H. Zhang and X. Zhuang, Chem. Commun., 2010, 46, 5710 DOI: 10.1039/C0CC00477D

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