Microtubes self-assembled from a cholesterol-modified nucleoside

Paula Pescador; Nicolai Brodersen; Holger A. Scheidt; Martin Loew; Gudrun Holland; Norbert Bannert; Jürgen Liebscher; Andreas Herrmann; Daniel Huster; Anna Arbuzova

doi:10.1039/C0CC00562B

Microtubes self-assembled from a cholesterol-modified nucleoside†

Paula Pescador,*^a Nicolai Brodersen,^b Holger A. Scheidt,^ac Martin Loew,^d Gudrun Holland,^e Norbert Bannert,^e Jürgen Liebscher,^b Andreas Herrmann,^d Daniel Huster^a and Anna Arbuzova*^d

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^a Institute of Medical Physics and Biophysics, University of Leipzig, Härtelstr. 16-18, 04107 Leipzig, Germany
E-mail: paula.pescador@medizin.uni-leipzig.de
Fax: +49 341 9715709
Tel: +49 341 9715726

^b Institute of Chemistry, Humboldt-University Berlin, Brook-Taylor-Str. 2, 12489 Berlin, Germany

^c Institute of Biotechnology, Martin Luther University Halle-Wittenberg, Kurt-Mothes-Str. 3, 06120 Halle, Germany

^d Institute of Biology/Biophysics, Humboldt-University Berlin, Invalidenstr. 42, 10115 Berlin, Germany
E-mail: arbuzova@cms.hu-berlin.de
Fax: +49 30 20938585
Tel: +49 30 20939017

^e Robert Koch Institute, Nordufer 20, 13353 Berlin, Germany

Abstract

We describe the formation of lipid microtubes from a novel cholesterol-modified nucleoside in binary mixture with phospholipids. Stable cylindrical structures with an outer diameter of 2–3 μm and a length of 20–40 μm were formed. By varying the preparation conditions, thinner tubules with nanometre-scale diameters could also be obtained.

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Microtubes self-assembled from a cholesterol-modified nucleoside†

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Microtubes self-assembled from a cholesterol-modified nucleoside

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