Issue 26, 2010

Total synthesis of the proposed structure of iriomoteolide-1a

Abstract

The total synthesis of the proposed structure of iriomoteolide-1a has been accomplished via a Yamaguchi esterification and ring closing metathesis sequence between the C(7)–C(23) and newly synthesized Z-alkenoic acid C(1)–C(6) fragments. The spectral data of the synthetic 1, however, is at odds with data reported for the natural product, thus bringing into question the original structural assignment.

Graphical abstract: Total synthesis of the proposed structure of iriomoteolide-1a

Supplementary files

Article information

Article type
Communication
Submitted
28 Mar 2010
Accepted
21 Apr 2010
First published
18 May 2010

Chem. Commun., 2010,46, 4770-4772

Total synthesis of the proposed structure of iriomoteolide-1a

J. Xie, Y. Ma and D. A. Horne, Chem. Commun., 2010, 46, 4770 DOI: 10.1039/C0CC00628A

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