Issue 33, 2010
From the journal:

Chemical Communications

Design of novel RNA ligands that bind stem–bulge HIV-1 TAR RNA†

Maria Duca,a   Vincent Malnuit,a   Florent Barbaultb  and  Rachid Benhida*a  

* Corresponding authors

a LCMBA UMR6001 CNRS Université de Nice Sophia Antipolis, Faculté des Sciences, Parc Valrose 06100, Nice, France
E-mail: benhida@unice.fr
Fax: +33-4-92076151
Tel: +33-4-92076174

b Université Paris Diderot, Laboratoire ITODYS, 15 rue Jean de Baïf, bâtiment Lavoisier, 75013 Paris, France

Abstract

We report here the rational design and the synthesis of a new series of RNA ligands. These molecules are constituted of various binding motifs that interact cooperatively with HIV-1 TAR RNA, used as a model.

Graphical abstract: Design of novel RNA ligands that bind stem–bulge HIV-1 TAR RNA

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Article information

DOI
https://doi.org/10.1039/C0CC00645A
Article type
Communication
Submitted
29 Mar 2010
Accepted
25 Jun 2010
First published
23 Jul 2010

Chem. Commun., 2010,46, 6162-6164

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Design of novel RNA ligands that bind stem–bulge HIV-1 TAR RNA

M. Duca, V. Malnuit, F. Barbault and R. Benhida, Chem. Commun., 2010, 46, 6162 DOI: 10.1039/C0CC00645A

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