Issue 35, 2010
From the journal:

Chemical Communications

The role of double hydrogen bonds in asymmetric direct aldol reactions catalyzed by amino amide derivatives

Xiao-Hua Chen,a   Jie Yua  and  Liu-Zhu Gong*a  

* Corresponding authors

a Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, China
E-mail: gonglz@ustc.edu.cn

Abstract

The double hydrogen bonding activation of carbonyl functionality has been a general strategy for the design of amino amide organocatalysts for highly enantioselective direct aldol reactions of various ketones with aldehydes conducted in either organic solvents or aqueous media. Moreover, this concept may suggest an activation mode to create new catalysts for other related asymmetric transformations.

Graphical abstract: The role of double hydrogen bonds in asymmetric direct aldol reactions catalyzed by amino amide derivatives

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Article information

DOI
https://doi.org/10.1039/C0CC00754D
Article type
Feature Article
Submitted
03 Apr 2010
Accepted
29 Jun 2010
First published
06 Aug 2010

Chem. Commun., 2010,46, 6437-6448

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The role of double hydrogen bonds in asymmetric direct aldol reactions catalyzed by amino amide derivatives

X. Chen, J. Yu and L. Gong, Chem. Commun., 2010, 46, 6437 DOI: 10.1039/C0CC00754D

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