Issue 1, 2011

Primary amine-metal Lewis acid bifunctional catalysts based on a simple bidentate ligand: direct asymmetric aldol reaction

Abstract

A novel class of primary amine-metal Lewis acid bifunctional catalysts based on a bidentate ligand was developed. These catalysts were highly efficient in catalyzing the direct asymmetric aldol reactions of ketones offering excellent stereoselectivity. The aldol reactions required a low catalyst loading (2.5 mol%), and were water compatible.

Graphical abstract: Primary amine-metal Lewis acid bifunctional catalysts based on a simple bidentate ligand: direct asymmetric aldol reaction

Supplementary files

Article information

Article type
Communication
Submitted
13 Apr 2010
Accepted
01 Jun 2010
First published
21 Jun 2010

Chem. Commun., 2011,47, 224-226

Primary amine-metal Lewis acid bifunctional catalysts based on a simple bidentate ligand: direct asymmetric aldol reaction

P. Daka, Z. Xu, A. Alexa and H. Wang, Chem. Commun., 2011, 47, 224 DOI: 10.1039/C0CC00917B

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