Issue 30, 2010

A copperradiopharmaceutical for diagnostic imaging of Alzheimer's disease: a bis(thiosemicarbazonato)copper(ii) complex that binds to amyloid-β plaques

Abstract

A bis(thiosemicarbazonato)copper(II) complex with an appended stilbene functional group binds to amyloid-β plaques that are associated with Alzheimer's disease. The complex has the potential to be of use as a copper-64 radiopharmaceutical to assist in the diagnosis of Alzheimer's disease by positron emission tomography.

Graphical abstract: A copper radiopharmaceutical for diagnostic imaging of Alzheimer's disease: a bis(thiosemicarbazonato)copper(ii) complex that binds to amyloid-β plaques

Supplementary files

Article information

Article type
Communication
Submitted
29 Apr 2010
Accepted
01 Jun 2010
First published
17 Jun 2010

Chem. Commun., 2010,46, 5437-5439

A copper radiopharmaceutical for diagnostic imaging of Alzheimer's disease: a bis(thiosemicarbazonato)copper(II) complex that binds to amyloid-β plaques

S. Lim, B. M. Paterson, M. T. Fodero-Tavoletti, G. J. O'Keefe, R. Cappai, K. J. Barnham, V. L. Villemagne and P. S. Donnelly, Chem. Commun., 2010, 46, 5437 DOI: 10.1039/C0CC01175D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements