Issue 34, 2010
From the journal:

Chemical Communications

Highly enantioselective hydroaminoalkylation of secondary amines catalyzed by group 5 metal amides with chiral biarylamidate ligands†

Guofu Zi,*a   Furen Zhanga  and  Haibin Songb  

* Corresponding authors

a Department of Chemistry, Beijing Normal University, Beijing 100875, China
E-mail: gzi@bnu.edu.cn
Fax: +86-10-58802075
Tel: +86-10-58807843

b State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China

Abstract

A highly enantioselective group 5 metal amide catalyst system is reported for the hydroaminoalkylation of secondary amines to give chiral amines in good yields with excellent ee values (up to 93%) by loading of 5% precatalyst.

Graphical abstract: Highly enantioselective hydroaminoalkylation of secondary amines catalyzed by group 5 metal amides with chiral biarylamidate ligands

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Article information

DOI
https://doi.org/10.1039/C0CC01265C
Article type
Communication
Submitted
06 May 2010
Accepted
21 Jun 2010
First published
29 Jul 2010

Chem. Commun., 2010,46, 6296-6298

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Highly enantioselective hydroaminoalkylation of secondary amines catalyzed by group 5 metal amides with chiral biarylamidate ligands

G. Zi, F. Zhang and H. Song, Chem. Commun., 2010, 46, 6296 DOI: 10.1039/C0CC01265C

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