Issue 28, 2010
From the journal:

Chemical Communications

An alkynylboronatecycloaddition strategy to functionalised benzyne derivatives†

James D. Kirkham,a   Patrick M. Delaney,a   George J. Ellames,b   Eleanor C. Rowb  and  Joseph P. A. Harrity*a  

* Corresponding authors

a Department of Chemistry, University of Sheffield, Sheffield, UK
E-mail: j.harrity@sheffield.ac.uk

b Department of Isotope Chemistry and Metabolite Synthesis, sanofi-aventis, Willowburn Avenue, Alnwick, UK

Abstract

A new approach to benzyne precursors has been developed that involves the [4+2] cycloaddition of trimethylsilyl alkynylboronates with 2-pyrones, followed by oxidation and trifluoromethylsulfonylation of the boronate moiety.

Graphical abstract: An alkynylboronate cycloaddition strategy to functionalised benzyne derivatives

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Article information

DOI
https://doi.org/10.1039/C0CC01345E
Article type
Communication
Submitted
11 May 2010
Accepted
04 Jun 2010
First published
16 Jun 2010

Chem. Commun., 2010,46, 5154-5156

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An alkynylboronate cycloaddition strategy to functionalised benzyne derivatives

J. D. Kirkham, P. M. Delaney, G. J. Ellames, E. C. Row and J. P. A. Harrity, Chem. Commun., 2010, 46, 5154 DOI: 10.1039/C0CC01345E

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