Issue 31, 2010
From the journal:

Chemical Communications

In vivo tumor diagnosis and photodynamic therapy via tumoral pH-responsive polymeric micelles†

Heebeom Koo,‡a   Hyejung Lee,‡ab   Sojin Lee,ac   Kyung Hyun Min,ab   Min Sang Kim,d   Doo Sung Lee,d   Yongseok Choi,c   Ick Chan Kwon,a   Kwangmeyung Kim*a  and  Seo Young Jeong*b  

* Corresponding authors

a Biomedical Research Center, Korea Institute of Science and Technology, Seongbuk-Gu, Seoul 136-791, South Korea
E-mail: kim@kist.re.kr
Fax: (+82) 2-958-5909
Tel: (+82) 2-958-5912

b Department of Life and Nanopharmaceutical Science, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, South Korea
E-mail: syjeong@khu.ac.kr
Fax: (+82) 2-966-3885
Tel: (+82) 2-961-9254

c School of Life Science and Biotechnology, Korea University, 1 Anam-dong, Seongbuk-gu, Seoul 136-701, South Korea

d Department of Polymer Science and Engineering, Sungkyunkwan University, Suwon 440-746, South Korea

Abstract

We report protoporphyrin IX (PpIX) encapsulated pH-responsive micelles for cancer treatment. This system showed pH-responsive micellization/demicellization transition at tumoral acidic pH and enabled in vivo tumor diagnosis and therapy simultaneously.

Graphical abstract: In vivo tumor diagnosis and photodynamic therapy via tumoral pH-responsive polymeric micelles

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Article information

DOI
https://doi.org/10.1039/C0CC01413C
Article type
Communication
Submitted
14 May 2010
Accepted
25 Jun 2010
First published
09 Jul 2010

Chem. Commun., 2010,46, 5668-5670

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In vivo tumor diagnosis and photodynamic therapy via tumoral pH-responsive polymeric micelles

H. Koo, H. Lee, S. Lee, K. H. Min, M. S. Kim, D. S. Lee, Y. Choi, I. C. Kwon, K. Kim and S. Y. Jeong, Chem. Commun., 2010, 46, 5668 DOI: 10.1039/C0CC01413C

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