Issue 38, 2010
From the journal:

Chemical Communications

Molecular AND-logic for dually controlled activation of a DNA-binding spiropyran†

Martin Hammarson,a   Johanna Andersson,a   Shiming Li,a   Per Lincolna  and  Joakim Andréasson*a  

* Corresponding authors

a Department of Chemical and Biological Engineering, Physical Chemistry, Chalmers University of Technology, 412 96 Göteborg, Sweden
E-mail: a-son@chalmers.se
Fax: +46 31 772 38 58
Tel: +46 31 772 28 38

Abstract

A spiropyran photoswitch is activated using UV light and protons from a form that shows no interaction with DNA to a form that binds to DNA by intercalation. This scheme is interpreted as a biologically relevant logic AND gate with potential applications as a dually controlled anticancer drug.

Graphical abstract: Molecular AND-logic for dually controlled activation of a DNA-binding spiropyran

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Article information

DOI
https://doi.org/10.1039/C0CC01682A
Article type
Communication
Submitted
01 Jun 2010
Accepted
05 Aug 2010
First published
27 Aug 2010

Chem. Commun., 2010,46, 7130-7132

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Molecular AND-logic for dually controlled activation of a DNA-binding spiropyran

M. Hammarson, J. Andersson, S. Li, P. Lincoln and J. Andréasson, Chem. Commun., 2010, 46, 7130 DOI: 10.1039/C0CC01682A

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