Issue 36, 2010
From the journal:

Chemical Communications

Responsive and mitochondria-specific ruthenium(ii) complex for dual in vitro applications: two-photon (near-infrared) induced imaging and regioselective cell killing†

Hanzhong Ke,a   Hongda Wang,a   Wai-Kwok Wong,*be   Nai-Ki Mak,c   Daniel W. J. Kwong,b   Ka-Leung Wongb  and  Hoi-Lam Tamde  

* Corresponding authors

a Faculty of Material Science & Chemistry Engineering, China University of Geosciences, Wuhan, Hubei 430074, P. R. China

b Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, P. R. China
E-mail: wkwong@hkbu.edu.hk
Fax: 852-3411-5862
Tel: 852-34117011

c Department of Biology, Hong Kong Baptist University, Kowloon Tong, Hong Kong, P. R. China

d Department of Physics, Hong Kong Baptist University, Kowloon Tong, Hong Kong, P. R. China

e Centre for Advanced Luminescence Materials, Hong Kong Baptist University, Kowloon Tong, Hong Kong, P. R. China

Abstract

A mitochondria-permeable ruthenium(II) complex has been designed as a responsive probe which may be used to sensitize the formation of singlet oxygen (ΦΔ = 0.93) and cause local damage in cellulo when exposed to UV and near-infrared laser excitation.

Graphical abstract: Responsive and mitochondria-specific ruthenium(ii) complex for dual in vitro applications: two-photon (near-infrared) induced imaging and regioselective cell killing

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Article information

DOI
https://doi.org/10.1039/C0CC01848A
Article type
Communication
Submitted
11 Jun 2010
Accepted
03 Aug 2010
First published
18 Aug 2010

Chem. Commun., 2010,46, 6678-6680

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Responsive and mitochondria-specific ruthenium(II) complex for dual in vitro applications: two-photon (near-infrared) induced imaging and regioselective cell killing

H. Ke, H. Wang, W. Wong, N. Mak, D. W. J. Kwong, K. Wong and H. Tam, Chem. Commun., 2010, 46, 6678 DOI: 10.1039/C0CC01848A

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