Issue 34, 2010
From the journal:

Chemical Communications

Practical iron-catalyzed dehalogenation of aryl halides†

Waldemar Maximilian Czaplik,a   Sabine Grupe,a   Matthias Mayera  and  Axel Jacobi von Wangelin*a  

* Corresponding authors

a Department of Chemistry, University of Cologne, Greinstr. 4, 50939 Koeln, Germany
E-mail: axel.jacobi@uni-koeln.de
Fax: +49 (0)221 470 5057
Tel: +49 (0)221 470 6122

Abstract

An operationally simple iron-catalyzed hydrodehalogenation of aryl halides has been developed with 1 mol% Fe(acac)3 and commercial t-BuMgCl as reductant. The mild reaction conditions (THF, 0 °C, 1.5 h) effect rapid chemoselective dehalogenation of (hetero)aryl halides (I, Br, Cl) and tolerate F, Cl, OR, SR, CN, CO2R, and vinyl groups.

Graphical abstract: Practical iron-catalyzed dehalogenation of aryl halides

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Article information

DOI
https://doi.org/10.1039/C0CC01980A
Article type
Communication
Submitted
20 Jun 2010
Accepted
12 Jul 2010
First published
09 Aug 2010

Chem. Commun., 2010,46, 6350-6352

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Practical iron-catalyzed dehalogenation of aryl halides

W. M. Czaplik, S. Grupe, M. Mayer and A. J. V. Wangelin, Chem. Commun., 2010, 46, 6350 DOI: 10.1039/C0CC01980A

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