Issue 37, 2010
From the journal:

Chemical Communications

Copper-induced cytotoxicity: reactive oxygen species or islet amyloidpolypeptide oligomer formation†

Ye-Ping Yu,‡a   Peng Lei,‡a   Jia Hu,a   Wei-Hui Wu,a   Yu-Fen Zhaoa  and  Yan-Mei Li*a  

* Corresponding authors

a The Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of education), Department of Chemistry, Tsinghua University, Beijing 100084, China
E-mail: liym@mail.tsinghua.edu.cn
Fax: 8610 62781695
Tel: 8610 62796197

Abstract

Copper enhances amyloid cytotoxicity and mediates human islet amyloid polypeptide (hIAPP) oligomerization; nickel, a redox inactive metal with similar protein binding affinity to copper, also mimics this effect, thereby demonstrating copper-mediated hIAPP cytotoxicity is due mainly to granular oligomer generation rather than ROS accumulation in type 2 diabetes.

Graphical abstract: Copper-induced cytotoxicity: reactive oxygen species or islet amyloid polypeptide oligomer formation

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Article information

DOI
https://doi.org/10.1039/C0CC02141E
Article type
Communication
Submitted
28 Jun 2010
Accepted
09 Aug 2010
First published
23 Aug 2010

Chem. Commun., 2010,46, 6909-6911

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Copper-induced cytotoxicity: reactive oxygen species or islet amyloid polypeptide oligomer formation

Y. Yu, P. Lei, J. Hu, W. Wu, Y. Zhao and Y. Li, Chem. Commun., 2010, 46, 6909 DOI: 10.1039/C0CC02141E

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