Issue 2, 2011
From the journal:

Chemical Communications

Cooperative catalysis in highly enantioselective Mannich-type three-component reaction of a diazoacetophenone with an alcohol and an imine†

Xinfang Xu,a   Yu Qian,a   Liping Yanga  and  Wenhao Hu*a  

* Corresponding authors

a East China Normal University, Institute of Drug Discovery and Development, Department of Chemistry, Shanghai 200062, China
E-mail: whu@chem.ecnu.edu.cn

Abstract

A highly enantioselective three-component reaction of a diazoacetophenone, an alcohol, and an imine catalyzed cooperatively by Rh2(OAc)4 and BINOL-derived chiral phosphoric acid has been developed for the synthesis of chiral β-amino-α-hydroxyl ketones in good yield with excellent diastereo and enantio selectivity.

Graphical abstract: Cooperative catalysis in highly enantioselective Mannich-type three-component reaction of a diazoacetophenone with an alcohol and an imine

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Article information

DOI
https://doi.org/10.1039/C0CC03024D
Article type
Communication
Submitted
04 Aug 2010
Accepted
05 Nov 2010
First published
29 Nov 2010

Chem. Commun., 2011,47, 797-799

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Cooperative catalysis in highly enantioselective Mannich-type three-component reaction of a diazoacetophenone with an alcohol and an imine

X. Xu, Y. Qian, L. Yang and W. Hu, Chem. Commun., 2011, 47, 797 DOI: 10.1039/C0CC03024D

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