Issue 3, 2011

Organocatalytic enantioselective desymmetrization of cyclic enonesviaphosphine promoted [3+2] annulations

Abstract

Phosphine catalyzed enantioselective [3+2] cyclizations on 4-substituted 2,6-diarylidenecyclohexanones and 2,4-diarylidene-bicyclo[3.1.0]hexan-3-ones take place with high diastereo- and enantioselectivity levels. The process affords spirocyclic compounds with excellent stereochemical control of up to five stereogenic centres.

Graphical abstract: Organocatalytic enantioselective desymmetrization of cyclic enonesviaphosphine promoted [3+2] annulations

Supplementary files

Article information

Article type
Communication
Submitted
10 Aug 2010
Accepted
12 Oct 2010
First published
09 Nov 2010

Chem. Commun., 2011,47, 1015-1017

Organocatalytic enantioselective desymmetrization of cyclic enonesviaphosphine promoted [3+2] annulations

N. Pinto, P. Retailleau, A. Voituriez and A. Marinetti, Chem. Commun., 2011, 47, 1015 DOI: 10.1039/C0CC03164J

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