Issue 2, 2011
From the journal:

Chemical Communications

Oxygen catalyzed mobilization of iron from ferritin by iron(iii) chelate ligands†

Fadi Bou-Abdallah,*a   Justin McNally,a   Xing Xin Liub  and  Artem Melman*b  

* Corresponding authors

a State University of New York at Potsdam, Department of Chemistry, Potsdam, New York, USA
E-mail: bouabdf@potsdam.edu
Fax: +1 315 267-3170
Tel: +1 315 267-2268

b Clarkson University, Department of Chemistry & Biomolecular Science, Potsdam, New York, USA
E-mail: amelman@clarkson.edu
Fax: +1 315 268-6610
Tel: +1 315 268-4405

Abstract

Tridentate chelate ligands of 2,6-bis[hydroxy(methyl)amino]-1,3,5-triazine family rapidly release iron from human recombinant ferritin in the presence of oxygen. The reaction is inhibited by superoxide dismutase, catalase, mannitol and urea. Suggested reaction mechanism involves reduction of the ferritin iron core by superoxide anion, diffusion of iron(II) cations outside the ferritin shell, and regeneration of superoxide anions through oxidation of iron(II) chelate complexes with molecular oxygen.

Graphical abstract: Oxygen catalyzed mobilization of iron from ferritin by iron(iii) chelate ligands

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Article information

DOI
https://doi.org/10.1039/C0CC03454A
Article type
Communication
Submitted
24 Aug 2010
Accepted
18 Oct 2010
First published
08 Nov 2010

Chem. Commun., 2011,47, 731-733

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Oxygen catalyzed mobilization of iron from ferritin by iron(III) chelate ligands

F. Bou-Abdallah, J. McNally, X. X. Liu and A. Melman, Chem. Commun., 2011, 47, 731 DOI: 10.1039/C0CC03454A

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