Issue 2, 2011

A two step route to indoles from haloarenes—a versatile variation on the Fischer indole synthesis

Abstract

In a new variation on the Fischer indole synthesis, readily available haloarenes are converted into a wide range of indoles in just two steps by halogen-magnesium exchange, quenching with di-tert-butyl azodicarboxylate, followed by reaction with ketones under acidic conditions.

Graphical abstract: A two step route to indoles from haloarenes—a versatile variation on the Fischer indole synthesis

Supplementary files

Article information

Article type
Communication
Submitted
08 Oct 2010
Accepted
01 Nov 2010
First published
22 Nov 2010

Chem. Commun., 2011,47, 788-790

A two step route to indoles from haloarenes—a versatile variation on the Fischer indole synthesis

M. Inman and C. J. Moody, Chem. Commun., 2011, 47, 788 DOI: 10.1039/C0CC04306K

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