Issue 3, 2011

Nucleic acid detection using carbon nanoparticles as a fluorescent sensing platform

Abstract

In this communication, we demonstrate for the first time the proof of concept that carbon nanoparticles (CNPs) can be used as an effective fluorescent sensing platform for nucleic acid detection with selectivity down to single-base mismatch. The dye-labeled single-stranded DNA (ssDNA) probe is adsorbed onto the surface of the CNPvia π–π interaction, quenching the dye. In the target assay, a double-stranded DNA (dsDNA) hybrid forms, recovering dye fluorescence.

Graphical abstract: Nucleic acid detection using carbon nanoparticles as a fluorescent sensing platform

Supplementary files

Article information

Article type
Communication
Submitted
10 Oct 2010
Accepted
29 Oct 2010
First published
15 Nov 2010

Chem. Commun., 2011,47, 961-963

Nucleic acid detection using carbon nanoparticles as a fluorescent sensing platform

H. Li, Y. Zhang, L. Wang, J. Tian and X. Sun, Chem. Commun., 2011, 47, 961 DOI: 10.1039/C0CC04326E

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