Issue 9, 2011
From the journal:

Chemical Communications

Stereoselective construction of a 5-aza-spiro[2,4]heptane motif viacatalytic asymmetric 1,3-dipolar cycloaddition of azomethine ylides and ethyl cyclopropylidene acetate†

Tang-Lin Liu,a   Zhao-Lin He,a   Hai-Yan Tao,a   Yue-Peng Caibc  and  Chun-Jiang Wang*ab  

* Corresponding authors

a College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China
E-mail: cjwang@whu.edu.cn
Fax: +86-27-68754067

b Shanghai Institute of Organic Chemistry, 354 Fenglin Road, Shanghai 200032, China

c School of Chemistry and Environment, South China Normal University, China

Abstract

A direct and facile synthesis of highly functional 5-aza-spiro[2,4]heptanes, a valuable structural motif for drug discovery, is developed viacatalytic asymmetric 1,3-dipolar cycloaddition of cyclopropylidene acetate and azomethine ylides for the first time.

Graphical abstract: Stereoselective construction of a 5-aza-spiro[2,4]heptane motif viacatalytic asymmetric 1,3-dipolar cycloaddition of azomethine ylides and ethyl cyclopropylidene acetate

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Article information

DOI
https://doi.org/10.1039/C0CC04329J
Article type
Communication
Submitted
10 Oct 2010
Accepted
21 Dec 2010
First published
14 Jan 2011

Chem. Commun., 2011,47, 2616-2618

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Stereoselective construction of a 5-aza-spiro[2,4]heptane motif viacatalytic asymmetric 1,3-dipolar cycloaddition of azomethine ylides and ethyl cyclopropylidene acetate

T. Liu, Z. He, H. Tao, Y. Cai and C. Wang, Chem. Commun., 2011, 47, 2616 DOI: 10.1039/C0CC04329J

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